Seen on several servers: (Debian Squeeze fully patched, and Ubuntu 11.04 also fully patched):
ClamAV update process started at Sun Feb 17 21:53:24 2013
main.cld is up to date (version: 54, sigs: 1044387, f-level: 60, builder: sven)
WARNING: getpatch: Can't download daily-16682.cdiff from db.local.clamav.net
WARNING: getpatch: Can't download daily-16682.cdiff from db.local.clamav.net
WARNING: getpatch: Can't download daily-16682.cdiff from db.local.clamav.net
WARNING: getpatch: Can't download daily-16682.cdiff from db.local.clamav.net
WARNING: getpatch: Can't download daily-16682.cdiff from db.local.clamav.net
WARNING: Incremental update failed, trying to download daily.cvd
WARNING: Can't download daily.cvd from db.local.clamav.net
Trying again in 5 secs...
This, while DNS resolution works:
Non-authoritative answer:
db.local.clamav.net canonical name = db.uk.clamav.net.
Name: db.uk.clamav.net
Address: 81.91.100.173
Name: db.uk.clamav.net
Address: 163.1.3.8
Name: db.uk.clamav.net
Address: 193.1.193.64
Name: db.uk.clamav.net
Address: 217.135.32.99
Therefore, be aware def updates are currently failiing... no idea if it will automatically recover from itself.
In a nutshell, keep an eye on it! :)
BTW, the certificate used by https://mirror.ufs.ac.za/antimalware/clamav/ is not a properly signed one...